| 1983 | The Binding Site Ltd was founded and launched with a range of highly specific polyclonal antisera used by clinical researchers worldwide. |
| 1987 | IgG Subclass RID kits first launched for the investigation of immunodeficiency. |
| 1988 | The Binding Site Inc in San Diego, USA was founded, the product range and customer base for clinical research antibodies continued to grow. |
| 1990 | First FDA cleared commercially available human IgG subclass kits for routine automated clinical use launched. |
| 1992 | Received Queen's Award for Export Achievement |
| 1993 | The Binding Site GmbH in Heidelberg, Germany founded. Dominance achieved worldwide of the human IgG subclass testing market. |
| 1996 | The Binding Site France founded in Grenoble. |
| 2001 | The Binding Site Inc sign deal with Dynex technologies for distribution of their DSX fully automated EIA processor. |
| 2001 | First publication highlighting the clinical significance of Freelite in nonsecretory multiple myeloma patients is published in Blood. |
| 2003 | Publication highlighting the clinical utility of Freelite for the replacement of Bence Jones protein in The Lancet. |
| 2004 | First National guidelines for the incorporation of Freelite assays into the management of Primary Amyloidosis patients published in the British Journal of Haematology. |
| 2006 | Freelite incorporated into the National UK guidelines for the diagnosis and monitoring of Multiple Myeloma published in the British Journal of Haematology |
| 2006 | Mayo Clinic publish the first independent study in the USA recommending Freelite as a routine screening test in Mayo Clinic Proceedings. |
| 2007 | Number of DSX processors placed by The Binding Site in the USA reaches 150. |
| 2007 | The Binding Site Spain founded in Barcelona. |
| 2007 | Won Queen's Award for Enterprise in the category Innovation, for the Freelite serum free light chain assay |
| 2007 | Journal of the American Society of Nephrology publishes the first study using Haemodialysis for the removal of serum free light chains as measured by Freelite. |