Enzyme Immunoassays (EIA)
There are 51 BINDAZYME kits used for diagnosis and monitoring of systemic rheumatic and connective tissue diseases, rheumatoid arthritis, autoimmune vasculitis, antiphospholipid syndrome, coeliac disease and inflammatory bowel disease.
- Protocols are common - all incubations are 30 minutes and all assays are read at 450mm. This simplifies the test procedure and minimises manual errors.
- The common protocol also aids easy, accurate programming of automated systems.
- Many BINDAZYME panels of assays use common wash buffers and sample diluents, aiding easy, accurate programming of automated systems.
- Suitable for manual and automated testing - ideal for small and large test volume laboratories.
- Break-apart plate format offers cost-effective testing.
- Colour-coded, ready to use reagents allow easy and accurate processing.
Systemic Rheumatic and Connective Tissue Diseases
Rheumatic diseases collectively form a group of disorders that can affect connective tissue, joints, bone or muscle resulting in various diseases including systemic lupus erythematosus (SLE), polymyositis/dermatomyositis, scleroderma, Sjögren's syndrome, rheumatoid arthritis and primary biliary cirrhosis. Distinct profiles of autoantibodies directed to intracellular (cytoplasmic/nuclear) antigens can be detected in these systemic diseases and are included in many sets of diagnostic criteria. BINDAZYME ANA, dsDNA and ENA assays aid in establishing diagnostic and prognostic information for such disorders.
| Description | Pack | Code |
|---|---|---|
| ANA Screening Kit | 96 test | MK200 |
| 96 test 96 test | MK017 MK072 | |
| 96 test 96 test 96 test 96 test 96 test 96 test 96 test | MK201 MK303 MK304 MK305 MK306 MK307 MK308 | |
| ENA Profile Kit* | 12 test | MK300 |
* Not available in USA
Rheumatoid Arthritis (RA)
Anti-CCP2 autoantibodies appear to be extremely specific for rheumatoid arthritis (RA) (>95%). They occur early in RA and so can be particularly valuable in aiding diagnosis when clinical symptoms may not be easily distinguished from other conditions. An early diagnosis of RA and prompt commencement of appropriate treatment is particularly important if irreparable joint damage is to be prevented. Anti-CCP2 antibodies also show good predictive potential.
| Description | Pack | Code |
|---|---|---|
| Anti CCP2 Kit** | 96 test | MK090 |
** Not available in The Netherlands, Sweden, Norway, Finland, Denmark and Iceland
Anti-Neutrophil Cytoplasmic Antibodies (ANCA) - Associated Systemic Vasculitis
ANCA are autoantibodies that react with neutrophil specific antigens. The major ANCA antigens in patients with primary systemic small vessel vasculitis are the enzymes myeloperoxidase (MPO) and proteinase-3 (PR3), which are present within neutrophil granules. BINDAZYME EIA MPO and PR3 assays are used to confirm the specificity of ANCA antibodies identified in previous screening tests, e.g. Neutrophil immunofluorescence assays.
| Description | Pack | Code |
|---|---|---|
| Anti MPO IgG Kit | 96 test 10 x 96 test | MK031 MK031.10 |
| Anti PR3 IgG Kit | 96 test 10 x 96 test | MK032 MK032.10 |
| Anti GBM IgG Kit | 96 test 10 x 96 test | MK034 MK034.10 |
| C1q Binding CIC Kit | 96 test | MK021 |
Antiphospholipid Syndrome
Antiphospholipid syndrome (APS) is defined by the association between venous and/or arterial thrombosis, recurrent pregnancy loss, thrombocytopenia and the presence of anti phospholipid autoantibodies (aPLs). aPLs are a group of heterogeneous autoantibodies directed against phospholipids such as cardiolipin, phosphatidylserine and co-factor proteins such as beta 2-glycoprotein I (beta 2-GPI). BINDAZYME Phospholipid assays are used to confirm the type and levels of antiphospholipid antibodies to aid in APS diagnosis and treatment.
| Description | Pack | Code |
|---|---|---|
| 96 test 96 test 96 test 96 test 96 test | MK027 MK028 MK029 MK030 MK071 | |
| 96 test 96 test 96 test 96 test | MK040 MK041 MK042 MK043 | |
| 96 test 96 test 96 test 96 test 96 test 96 test 96 test 96 test | MK127 MK128 MK129 MK130 MK140 MK141 MK142 MK143 | |
| Anti Phosphatidylserine IgG Kit | 96 test 96 test 96 test | MK050 MK051 MK052 |
| Anti-phosphatidylinositol IgG/IgM COMBI kit*** NEW Anti-phosphatidylinositol IgA kit*** Anti-phosphatidic acid IgG/IgM COMBI kit*** NEW Anti-phosphatidic acid IgA kit*** Anti-phosphatidylglycerol IgG/IgM COMBI kit*** NEW Anti-phosphatidylglycerol IgA kit*** Anti-phosphatidylcholine IgG/IgM COMBI kit*** NEW Anti-phosphatidylcholine IgA kit*** Anti-phosphatidylethanolamine IgG/IgM COMBI kit*** NEW Anti-phosphatidylethanolamine IgA kit*** | 96 test 96 test 96 test 96 test 96 test 96 test 96 test 96 test 96 test 96 test | MK073 MK082 MK074 MK083 MK075 MK084 MK076 MK085 MK077 MK086 |
*** For research use only. Please contact us for further information.
Autoimmune Intestinal Disease
Coeliac Disease is an autoimmune disease caused by a genetically related increase in the activity of tissue transglutaminase (tTG), an enzyme found in the endomysial layer of the gut. Immunofluorescence assays and enzyme immunoassays are used for screening, specificity confirmation and quantitation of the autoantibodies involved ... more.
Inflammatory bowel disease exists in two major forms; ulcerative colitis and Crohn's disease. Recent studies have indicated two serological markers, ASCA and P-ANCA, may assist where the differentiation of ulcerative colitis and Crohn's disease is difficult ... more.
| Description | Pack | Code |
|---|---|---|
| Anti Tissue Transglutaminase IgG Kit | 96 test | MK019 |
| Anti Tissue Transglutaminase IgA Kit | 96 test | MK038 |
| NEW Anti Gliadin (MGP) IgG Kit | 96 test | MK135 |
| NEW Anti Gliadin (MGP) IgA Kit | 96 test | MK136 |
| NEW Anti Gliadin (MGP) IgG/IgA COMBI Kit | 96 test | MK137 |
| Anti Gliadin IgG Kit | 96 test | MK035 |
| Anti Gliadin IgA Kit | 96 test | MK036 |
| Anti Gliadin IgG/IgA COMBI Kit | 96 test | MK037 |
| ASCA (Anti Saccharomyces cerevisiae antibodies) IgG Kit | 96 test | MK053 |
| ASCA (Anti Saccharomyces cerevisiae antibodies) IgA Kit | 96 test | MK054 |
| Anti TPO (Thyroid Peroxidase) Kit | 96 test | MK039 |
| Anti Thyroglobulin Kit | 96 test | MK018 |
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