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New Cystatin C assay for Roche Modular P

March 18th 2008
New Cystatin C assay for Roche Modular P

Binding Site's new assay for the quantitation of cystatin C in human serum or plasma shows excellent precision and linearity, and is easily installed on the Roche P Module. The assay utilises calibrators and controls which are manufactured from human serum.

A recent publication (Flodin, M. et al) highlights the importance of using calibrators and controls that do not differ from patient samples, and the use of recombinant Cystatin C in other commercial assays has also proved to be problematic when measuring patient samples (Mojiminiyi, O.A. et al). Reagents for 100 tests are provided in a kit format including latex-enhanced reagent for high sensitivity, a set of 6 calibrators and high and low controls.

Cystatin C measurement can be used as an aid in the diagnosis and treatment of renal disease and is an ideal marker of Glomerular Filtration Rate (GFR). For Multiple Myeloma patients being monitored using Freelite® serum free light chain assays, measurement of Cystatin C could provide additional information regarding renal function.  

Flodin, M. et al (2006). Variations in assay protocol for the Dako Cystatin C method may change patient results by 50% without changing the results for controls. Clinical Chemistry and Laboratory Medicine, 44(12): 1481-1485.Mojiminiyi, O.A. et al. (2003). Evaluation of Cystatin C and β-2 microglobulin as markers of renal function in patients with type 2 diabetes mellitus. Journal of Diabetes and Its Complications, 17: 160-168.

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