New screening algorithm with Freelite® reduces labour-intensive IFE in Australian study
Serum free light chain assay reduces the need for serum and urine immunofixation electrophoresis in the evaluation of monoclonal gammopathy Richard B. Fulton and Suran L. Fernando. Ann Clin Biochem 2009;46: 407-12
The authors examined the optimal combination of laboratory tests to screen for monoclonal gammopathy. They commented: "The FLC ratio is a more sensitive method than uIFE in the detection of monoclonal light chains and may substantially reduce the need for onerous 24 h urine collections."
By changing from a strategy where specific assays were requested by clinicians to a standardised protocol which utilised SPE, serum free light chains and restricted the use of immunofixation electrophoresis (IFE), the detection of monoclonal (M)-proteins was maximised whilst significant reductions in labour costs were made.
Review a suggested Initial Screening Investigation protocol using Freelite® serum free light chains or contact us to request a copy of the Fulton & Fernando publication - code MKG543